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Symbol
Name
ID
Insr
insulin receptor
MGI:96575
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Hypertrophic cardiomyopathy
Disease(s) Associated with INSR
Donohue syndrome

Mouse Phenotypes
cardiovascular system phenotype
abnormal retina vasculature morphology
abnormal retina blood vessel morphology
abnormal retina blood vessel pattern
abnormal vascular plexus formation
increased cardiac muscle glycogen level
decreased myocardial fiber size
abnormal heart development
small heart
decreased heart left ventricle weight
decreased heart left ventricle posterior wall thickness
abnormal cardiovascular system physiology
decreased coronary flow rate
decreased cardiac output
abnormal cardiac muscle cell glucose uptake
decreased cardiac muscle cell glucose uptake
increased cardiac muscle cell glucose uptake
decreased cardiac muscle contractility
Availability Mouse Genotype
Insrtm1Khn/Insrtm1Khn
Tg(Ckmm-cre)5Khn/0  (conditional)
*
Insrtm1Khn/Insrtm1Khn
Tg(Myhca-cre)1Abel/0  (conditional)
Insrtm1Khn/Insrtm1Khn
Tg(Pdgfrb-cre)#Rha/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory